MECHANISM OF ACTION

Quatrefolic® 的作用机制与 5-甲基四氢叶酸专有成分的活性部分的作用有关。

5-甲基四氢叶酸源自四氢叶酸,通过了一系列的代谢反应。四氢叶酸是一些重要代谢反应的辅酶,作为各种一碳单位的受体和供体参与转运,参加核苷酸嘌呤和嘧啶的生物合成和几种重要氨基酸的新陈代谢。

与维生素B12共同作用,叶酸辅酶可以使高同型半胱氨酸转换为蛋氨酸,这种转换的缺乏与各种病理疾病密切相关

四氢叶酸到5-甲基四氢叶酸的转化是通过甲基四氢叶酸还原酶的作用完成的。有亚甲基四氢叶酸还原酶遗传缺陷的个体,这种转化有限的,这增加了这些人患某些特定疾病的风险。

补充5-甲基四氢叶酸可能优于补充叶酸,正是因为它可直接用来与高同型半胱氨酸反应,避免同型半胱氨酸血症的发生。

叶酸生化循环的主要组成部分。DHFR = 二氢叶酸还原酶;MTHFR = 甲基四氢叶酸还原酶。

反应:

途径 1-生物合成的核苷酸并入DNA 和 RNA;
途径 2-再次甲基化的同型半胱氨酸形成蛋氨酸 (维生素 B12作为该反应的辅酶);
3-甲基化基底,包括 DNA、 RNA、 磷脂和蛋白质;
4-MTHFR 催化生成 5-甲基四氢叶酸需要甲基化反应;
5-二氢叶酸还原酶。

Folate Cycle

Quatrefolic® 补充剂允许 5-甲基四氢叶酸直接被利用,因为它的生物活性在机体内不会被破坏。

Quatrefolic® 太可能掩盖维生素 B12的缺乏,跟叶酸相比,Quatrefolic®具有实际优势并且更安全。

作为(6S)-5-甲基四氢叶酸直接来源的 Quatrefolic ® ,不太可能掩盖维生素 B12缺乏的表征。

Once formed, 5-methyltetrahydrofolate reacts with homocysteine by a single enzyme regulated by vitamin B12, leading to a recycling production of tetrahydrofolic acid.

If vitamin B12 is deficient, the folate present in cells becomes "metabolically trapped" and 5-methyltetrahydrofolate is piled up in the cells, resulting in a persistent impairment of purine and pyrimidine biosynthesis (pathway 1) and in a methylation cycle block (pathway 2), leading to megaloblastic anemia and neurological damage progress.

Vitamin B12 deficiency is common in old age and may not be easy to recognise. Folic acid intake by supplementation may mask first symptoms of vitamin B12 deficiency, such as anemia, while 5-methyltetrahydrofolate supplementation does not. Actually folic acid supplementation may activate synthesis of purine and pyrimidine through pathway 1 correcting anemia, although vitamin B12 is absent; on the contrary the pathway 2 remains blocked leading to a nerve and cognitive deterioration that may continue unchecked.

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